Targets for the Induction of Protective Immunity Against Influenza A Viruses
Identifieur interne : 000E16 ( Main/Exploration ); précédent : 000E15; suivant : 000E17Targets for the Induction of Protective Immunity Against Influenza A Viruses
Auteurs : Rogier Bodewes ; Albert D. M. E Osterhaus ; Guus F. RimmelzwaanSource :
- Viruses [ 1999-4915 ] ; 2010.
Abstract
The current pandemic caused by the new influenza A(H1N1) virus of swine origin and the current pandemic threat caused by the highly pathogenic avian influenza A viruses of the H5N1 subtype have renewed the interest in the development of vaccines that can induce broad protective immunity. Preferably, vaccines not only provide protection against the homologous strains, but also against heterologous strains, even of another subtype. Here we describe viral targets and the arms of the immune response involved in protection against influenza virus infections such as antibodies directed against the hemagglutinin, neuraminidase and the M2 protein and cellular immune responses directed against the internal viral proteins.
Url:
DOI: 10.3390/v2010166
PubMed: 21994606
PubMed Central: 3185556
Affiliations:
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M. E" last="Osterhaus">Albert D. M. E Osterhaus</name></author><author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The current pandemic caused by the new influenza A(H1N1) virus of swine origin and the current pandemic threat caused by the highly pathogenic avian influenza A viruses of the H5N1 subtype have renewed the interest in the development of vaccines that can induce broad protective immunity. Preferably, vaccines not only provide protection against the homologous strains, but also against heterologous strains, even of another subtype. Here we describe viral targets and the arms of the immune response involved in protection against influenza virus infections such as antibodies directed against the hemagglutinin, neuraminidase and the M2 protein and cellular immune responses directed against the internal viral proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bush, Rm" uniqKey="Bush R">RM Bush</name></author><author><name sortKey="Bender, Ca" uniqKey="Bender C">CA Bender</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Fitch, Wm" uniqKey="Fitch W">WM Fitch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Dj" uniqKey="Smith D">DJ Smith</name></author><author><name sortKey="Lapedes, As" uniqKey="Lapedes A">AS Lapedes</name></author><author><name 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Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Townsend, A" uniqKey="Townsend A">A Townsend</name></author><author><name sortKey="Bodmer, H" uniqKey="Bodmer H">H Bodmer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smallman Raynor, M" uniqKey="Smallman Raynor M">M Smallman-Raynor</name></author><author><name sortKey="Cliff, Ad" uniqKey="Cliff A">AD Cliff</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bodewes, Rogier" sort="Bodewes, Rogier" uniqKey="Bodewes R" first="Rogier" last="Bodewes">Rogier Bodewes</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E" last="Osterhaus">Albert D. M. E Osterhaus</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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